Abstract: The β 2 MG, Alb level is measured in 95 abnormal subjects of different kidney diseases and 40 normal subjects by RIA. The concentration of the serum and urine β 2 MG and urine Alb is 2.4+0.5, 0.3±0.1,20.4±6.7 mg/L in the acute glomerulonephritis group, 4.6 ±2.2, 0.6±0.3, 61.2±11.4 mg/L in the chronic geomerulonephritis group, 1.7± 0.4, 0.3±0.1, 6.1±2.1 mg/L in the normal group respectively. The results indicate that the measuring of the serum and urine β 2 MG and urine Alb is valuable in the diagnosis of different kidney diseases.