~(123)I-β-CIT:一种新型多巴胺转运体显像剂

An New Imaging Agent for SPECT of Dopamine Transporter: ~(123)I-β-CIT

摘要: :12 3 I- β- CIT是一种新型多巴胺转运体 SPECT显像剂, 具有亲和力高, 脑滞留时间长, 以及纹状体与小脑摄取比较高等特点。它对帕金森氏病的早期诊断、临床分期、疗效观察有较高的临床应用价值。本文介绍了 12 3 I- β- CIT在标记、药物动力学、毒性及临床应用等方面的研究结果, 并提出了今后在 DAT显像剂方面的发展方向

Abstract: I-β-CIT, 123 I- (2β-carbomethoxy-3β-4-iodophenyl-tropane),is a potential imaging agent for SPECT of dopamine transporter with high affinity, slow brain kinetics and high uptake ratio of striatum and cerebellum. The studies of 123 I-β-CIT on its labeling,kinetics and clinical appliance are introduced.