Abstract: In situs hybridization histochemical technique is applied to detect the expression of five subtype of human somatostatin receptor Mrna (hSSTR1~5), including the expression model of 54 cases of various tumor specimen and the expression density of 24 lung cancer cases. The results indicate that hSSTR1~5 is expressed in tumor in varying degrees, and is not found in normal tissues, hSSTR1~5 is expressed differently in varying tumor tissues. So it is potential to select the specific somatostatin analogue as the carrier of radionuclide for diagnosis tumor with imaging and tumor therapy directly.