Abstract: It has a direct proportin correlation between the epidermal growth factor receptor levels of tumour and tumour differentiation degree, tumour sizes, stage, mototic index or cancer recurrence. Epidermal growth factor receptor is detected in 90% of the tumours, in which, 54% of epidermal growth factor receptor of malignant tumours can link with external genous ligand. Therefore, radionuclinde labelled epidermal growth factor will bring about the imaging diagnosis and therapy of malignant tumours. The research present situation and clinical significance of radionuclinde labelled epidermal growth factor for receptor imaging diagnosis and therapy of tumour are emphatically elaborated in the paper.