Abstract: DIRECT INJECTION 90YGTMS FOR TREATMENT OF TRANSPLANTED LIVER NEOPLASM ——THE RELATIONSHIP BETWEEN DOSE AND THERAPEUTIC EFFECTZhang Jinming\ Tian Jiahe\ Dong Baowei\ Long Lijuan\ Li Junlai(Chinese PLA General Hospital, Beijing 100853)Jin Xiaohai\ Wang Fan\ Liu Yuemin(Department of Isotope, China Institute of Atomic Energy, Beijing 102413)ABSTRACT90Y glass microsphere is tested for mice transplanted liver neoplasm by direct injection into the tumor. The results show that the tumor，s growths in treated groups have been inhibited when the injecting dose added to 7.5 MBq/cm3. The absorbed dose is about 106.6 Gy at the edge of tumor. The total absorbed dose is up to 136.7 Gy. The tumors coagulate necrosis is more than 50%. In conclusion, direct injection 90YGTMS into the tumor could be achieved a higher radiation dose to tumor. It could be cured if the edge of tumor receive enough radiation dose. The technique might be expected to be one of a reliable and effective method for treating liver cancer.Key words\ 90YGTMS internal radiotherapy liver neoplasm internal radiation dosetherapeutic effect