2,2-二溴-1,1-二甲基乙基锗倍半氧化物的合成、~(125)I 标记和动物体内分布

摘要: 合成了２，２－二溴－１，１－二甲基乙基锗倍半氧化物，并用１２５Ｉ对其进行了标记，得到了最佳的标记条件，即标记时间为４０ｍｉｎ、反应温度为４０℃时，标记率可达９７．７％。２，２－二溴－１，１－二甲基乙基锗倍半氧化物的碘标记物在小白鼠体内的分布实验表明，该化合物在小白鼠的肾和肝中浓集最高。该化合物能否被肿瘤细胞摄取有待做进一步实验研究。

Abstract: STUDIES OF SYNTHESIS，125I LABELLING AND ANIMAL DISTRIBUTION OF BIBROMINE1,1BIMETHYLETHYL GERMANUM SESQUIOXIDELi Taihua Yang Shuyan(Department of Chemistry, Beijing Normal University, Beijing 100875)ABSTRACTBibromine1，1bimethylethyl germanum sesquioxide is synthesized, and then it is labelled with 125I. The labelled yield can be reached to 97.7% in the conditions of the reaction temperature 40 ℃ and the reaction time 40 min. The distribution in mouse show there is high uptake in kidney and liver. It should be studied whether the bibromine1,1bimethylethyl germanum sesquioxide can be uptake by tumor.Key words bibromine1，1bimethylethyl germanum sesquioxide 125I labelling animal distribution