Abstract: STUDIES ON LIVERTAXIS OF ANTINEOPLASTIC AGENT NGADHAQ AND ITS MECHANISMGuan Changtian Li Lin Li Yunchun(1st University Hospital, West China University of Medical Sciences, Chengdu 610041)Chen Wen Li Tongling Pang Qijie(School of Pharmacy, West China University of Medical Sciences, Chengdu 610041)ABSTRACTThe livertaxis of antineoplastic agent galactosylneoglycoalbuminmitoxantrone(NGADHAQ) and its mechanism using radioactive tracer technique is studied. NGA is a synthetic ligand specific for asialoglycoprotein receptor, which existed in the mammalian liver only. NGA as a carrier of hepatic targeting agents is coupled with an antineoplastic agent DHAQ via a butanediamide bridge to form a coujugator. NGADHAQ is labelled with 99Tcm. The data of rabbit and chick imaging, distribution in mice and HPLC assay are obtained. The results revealed that DHAQ has remarkable livertaxis and its uptake in liver is over 65% with the feature of receptormediated binding to hepatocytes in vivo. The results show that NGADHAQ is a potential receptormediated hepatic targeting antineoplastic agent.Key words antineoplastic agents galactosyl neoglycoalbuminmitoxantrone(NGADHAQ) liver cancer pharmacology livertaxis