Abstract:
STUDYONMOLERATIOVERSUSTHESTABILITYOF153Sm┐EDTMPJinXiaohaiBaiHongshengDuJinWangFanChenDamingLiuYuemin(DepartmentofIsotope,ChinaInstituteofAtomicEnergy,Beijing102413)ZhangJinming(ChinesePLAGeneralHospital,Beijing100853)ABSTRACT153Sm-EDTMP,asapaliationtherapeuticagentforpatientwithdisseminatedskeletalmetastases,iswidelyresearchedinrecentyears.TheefectsofmoleratioofEDTMPand153Smontheuptakeofliverforhighorlowspecificactivityof153Sm-EDTMPunderdiferentexperimentalconditionsareinvestigatedindetail.Theresultsshowthatthe153Sm-EDTMPstabilitywouldbemuchhigherinvivo,whenthemoleratioofEDTMPandSm(enrichedtarget)isupto1001orthemoleratioofEDTMPandSm(naturetarget)amountsto61.Theradiationdoseandphosphatebuferalsoafectthestabilityof153Sm-EDTMP.Keywordsstability153Sm-EDTMPradiationdosemoleratio