~(19)F-NMR 方法验证无载体 ~(18)FDG 合成的异构选择性

摘要: 采用穴状配体氨基聚醚２．２．２催化下的亲核取代反应，以１９ＦＦ－（ＫＦ）代替１８ＦＤＧ合成中的１８ＦＦ－与前体化合物１，３，４，６－四氧乙酰基－２－氧三氟甲烷磺酰基－β－右旋吡喃甘露糖反应，应用１８ＦＤＧ自动合成系统制备１９ＦＤＧ，并用１９Ｆ－ＮＭＲ方法验证了无载体１８ＦＤＧ合成的异构体选择性

Abstract: EPIMERIC SELECTIVITY IDENTIFICATION OF NOCARRIER ADDED 18FDG　SYNTHESIS　BY　19FNMR　SPECTROSCOPYZhao Guizhi Long Weizhong Li Dakang Wang Yishan(China Institute of Atomic Energy, Beijing 102413)ABSTRACTUsing the 18FDG autosynthesizing system and cryptand kryptofix 2.2.2 supported nucleophilic substitution, 19FDG is prepared by the reaction of 19F-（KF），instead of 18FF－ in the synthesis of 18FDG， with precursor 1,3,4,6tetraOacetyl2Otrifluoromethane sulfonylβDmannopyranose, and the epimeric selectivity of nocarrieradded 18FDG synthesis is identified by 19FNMR　spectroscopy.Key words 19FNMR 18FDG epimeric selectivity