30 例 AFP 阴性原发性肝癌患者 CEA 和 CA50 联合检测探讨

  • 摘要: 对30例AFP阴性原发性肝癌(PHC)伴腹水患者用放射免疫分析(RIA)进行血清及腹水CEA、CA50含量联合检测,并与26例AFP阳性PHC伴腹水患者、35例肝硬化腹水患者的血清及腹水CEA、CA50含量作比较。结果显示:AFP阴性PHC组血清及腹水CEA含量平均值均显著增高,阳性率73.3%,而AFP阳性组的阳性率为30.8%,两组CEA含量比较P<0.01,两组CA50含量比较无显著性差异(P>0.05);但两组与肝硬化腹水组对比则呈非常显著与显著性差异(对于CEA,P<0.001-0.01;对于CA50,P<0.05))。结果提示:对PHC患者特别是AFP阴性者进行AFP、CEA、CA50联合检测有临床实用价值。

     

    Abstract: APPROACHTOCOMBINEDDETECTIONOFCEA&CA50FOR30CASESOFPRIMARYHEPATICCARCINOMAPATIENTSWITHAFPNEGATIVEZhangLiminJiangTingying*HeSiufangWuLianzhu(FirstHospitalofYuhang,ZhejiangProvince,311100)(*CentreofMedicalRadioimmunologicofHangzhou,ZhejiangProvince,311015)ABSTRACTTakingadvantageofRIAmethod,thecombineddetectionofCEAandCA50inserumandascitesfor30caseswithAFPnegativeofPHCarecarriedout.ComparingwiththeAFPpositivegroupandhepatocirroneumascitesgroup,ThecontentsofAFP、CEAandCA50aremarkedlyhighfortheAFPnegativegroup.DataindicatethatthecombineddetectionofAFP、CEAandCA50isvaluableinclinicpracticeforpatientswithPHC,especialyforoneswithAFPnegative.Keywordsprimaryhepaticcarcinoma(PHC)ascitesα-fetoproteincarcinomaem-bryoantigen(CEA)carbohydrateantigen50(CA50)

     

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