~(99)(Tc)~m-ECD脂溶性成分在血液中的变化规律

  • 摘要: 99Tcm-ECD弹丸注射后,血中放射性浓度迅速增高,1min时达到峰值。全血脂溶性分数Nw在注射后0.5min时最大,随着时间的推移Nw快速变小。1min时Nw为0.76±0.06。99Tcm-ECD的全血时间变化常数Wb(t)为0.81±0.03。Wb(t)和放射化学纯度Rp的乘积与Nw显著正相关(r=0.999,P<0.001)。

     

    Abstract: REGULARCHANGESOFLIPOPHILIC99Tcm┐ECDINBLOODJiaShaoweiGuoYilingLiangGuirong(ShenzhenPeople,sHospital,518020)ABSTRACTTheradioactivityconcentrationincreasesquicklyfolowingtheinjectionof99Tcm-ECDintovenousas“bolus”,reachingapeakin1min.Thewholebloodlipophilicfraction(Nw)ap-prochesmaximumin0.5minafterinjection,andthenreducesquicklywiththelapseoftime.Thevalueis0.76±0.06in1min.ThewholebloodlipophilicconstantWb(t)is0.81±0.03.NwandtheproductofWb(t)andtheradiochemicalpurityRpshowahighlysignificantcorre-lation(r=0.999,P<0.001).Keywordscerebralbloodflowlipophilic99Tcm-ECDSPECT

     

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