血清CEA、SF、β_2-MG RIA联合检测对肺癌诊断及疗效观察的临床价值

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作者. 血清CEA、SF、β_2-MG RIA联合检测对肺癌诊断及疗效观察的临床价值[J]. 同位素, 1997, 10(1): 41-42+4. DOI: 10.7538/tws.1997.10.01.0041
引用本文: 作者. 血清CEA、SF、β_2-MG RIA联合检测对肺癌诊断及疗效观察的临床价值[J]. 同位素, 1997, 10(1): 41-42+4. DOI: 10.7538/tws.1997.10.01.0041

血清CEA、SF、β_2-MG RIA联合检测对肺癌诊断及疗效观察的临床价值

  • 摘要: 用放射免疫分析法(RIA)检测了109例肺癌患者(腺癌35例、鳞癌32例、小细胞癌42例)及对照组30例的血清CEA、SF、β2-MG含量,并对20例肺癌患者化疗前、后的含量变化进行比较。结果表明,肺癌组血清CEA、SF、β2-MG含量显著高于对照组(P<0.01),其单检阳性率依次为56.9%、72.5%、47.7%,而CEA、SF、β2-MG联检阳性率可达91.7%。化疗后肺癌患者β2-MG含量与化疗前自身对照无明显下降(P>0.05),而CEA与SF则明显下降(P<0.01)。由此说明,上述三项指标联检对肺癌诊治具有重要的临床价值。
    Abstract: COMBINEDRADIOIMMUNOASSAYOFSERUMCEA,SFANDβ2┐MGFORCLINICALDIAGNOSISANDOBSERVATIONOFLUNGCANCERZhaoRongqingChenHuilingZhuHaiming(HenanTumourHospital,Zhengzhou450003)ABSTRACTThecontentsoftheserumCEA,SFandβ2-MGfor109casesoflungcancer(35adenocar-cinomacases,32squamouscelcarcinomacasesand42smalcelcarcinomacases)and30nor-malcontrolsaredeterminedbyRIA.Thepre-andpost-chemotherapeuticchangesareobservedfor20casesoflungcancer.TheresultsshowthatthevalueofserumCEA,SFandβ2-MGofthe109casesisclearlyoverthatofthenormalcontrols(P<0.01)withthepositiveratesbeing56.9%,72.5%and47.7%,respectively.Thepositiverateofthecombiningassaycanbeashighas91.7%.Thepost-chemotherapeuticβ2-MGcontentofpatientswithlungcancershowsnoapparentdecline(P>0.05).However,theirserumCEAandSFdeclinesharply(P<0.01).TheabovestudiesrevealthatthecombinedRIAisofsignificantclinicalvalueinthediagnosisoflungcancer.Keywordscarcino-embryonicantigen(CEA)serumferitin(SF)β2-microglobulin(β2-MG)radioimmunoassay(RIA)lungcancer
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出版历程
  • 刊出日期:  1997-02-19

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