Abstract:
COMBINEDRADIOIMMUNOASSAYOFSERUMCEA,SFANDβ2┐MGFORCLINICALDIAGNOSISANDOBSERVATIONOFLUNGCANCERZhaoRongqingChenHuilingZhuHaiming(HenanTumourHospital,Zhengzhou450003)ABSTRACTThecontentsoftheserumCEA,SFandβ2-MGfor109casesoflungcancer(35adenocar-cinomacases,32squamouscelcarcinomacasesand42smalcelcarcinomacases)and30nor-malcontrolsaredeterminedbyRIA.Thepre-andpost-chemotherapeuticchangesareobservedfor20casesoflungcancer.TheresultsshowthatthevalueofserumCEA,SFandβ2-MGofthe109casesisclearlyoverthatofthenormalcontrols(P<0.01)withthepositiveratesbeing56.9%,72.5%and47.7%,respectively.Thepositiverateofthecombiningassaycanbeashighas91.7%.Thepost-chemotherapeuticβ2-MGcontentofpatientswithlungcancershowsnoapparentdecline(P>0.05).However,theirserumCEAandSFdeclinesharply(P<0.01).TheabovestudiesrevealthatthecombinedRIAisofsignificantclinicalvalueinthediagnosisoflungcancer.Keywordscarcino-embryonicantigen(CEA)serumferitin(SF)β2-microglobulin(β2-MG)radioimmunoassay(RIA)lungcancer