Abstract: THE DIAGNOSTIC VALUE OF GLYCOCHOLIC ACID FOR INTRAHEPATIC CHOLESTASIS IN PREGNANCY Wang Guangxian;Zhou Rong;Wan Baijian; Zhang Ruixuan;Wang Xiaofang(Nanjing the 81th Hospital, 210002)Abstract:The content of glycocholic acid(CG)in pregnant women's sera is detected with CG radioim munoassay(RIA).The content of CG in sera of normal pregnant women after 32 weeks is ascended slightly with the increasing of pregnant month. It is less than 7.0 μmol/l before 31 weeks in pregnancy and less than 9. 4 μmol/l after 32 weeks. The serum CG content of patients with intrahepatic cholestasis in pregnancy(ICP)is increased by 100%. The CG value of about half patients appears ear lier than pruritus and ALT rise, the earliest CG increasing appears in the 20th pregnant week.It is the most sensitive method for ICP early diagnosis.136 cases of ICP patients are observed and the results show that the higher the CG content,the higher the rate of intrauterine fetal anoxia;therefore, the dy namic observation of CG content in ICP patients is a dependable objective for surveillance of fetal prog nosis.Keywords: RIA intrahepatic cholestasis glycocholic acid