~(131)I-间碘苄胍稳定性的研究

  • 摘要: 为控制131I-MIBG内游离131I的含量,研究了自由基清除剂苯甲醇、抗坏血酸、龙胆酸对131I-MIBG分解的抑制作用。结果表明:1%的苯甲醇可有效地增加131I-MIBG的稳定性,室温下存放74MBq/ml的131I-MIBG,7d后溶液内游离131I的含量不超过5%;同时用1%苯甲醇作稳定剂时,131I-MIBG的分解不受温度和体积影响,主要受放射性浓度的影响。

     

    Abstract: STUDIES ON THE STABILITY OF~(131)I-MIBGZhang Jinming; Tian jiahe (The Chinese PLA General Hospital, Beijing 100853)Jin Xiaohai;Lin Qiongfang(China Institute of Atomic Energy,Beijing 102413)Abstract: In order to limit the free 131I content,the stability of 131I-MIBG contained different radical scavengers such as benzylalcohol,ascorbic acid and gentisic acid are studied.The resultS show 1% ben zylalcohol can inhibit the decompositions of 131I-MIBG effectively.The percentage of free 131I is lower than 5% When 131I-MIBG are stored in 74 MBq/ml at room temperature for 7 days with added 1 %benzylalcohol. The stability of 131I-MIBG doesn't affect by the store temperature(-20-20℃)and volume(1-10ml)when 1% benzylalcohol is used as stabilzer.Keywords:~(131)I-MIBG decomposition reaction radical scavengers stability

     

/

返回文章
返回