Abstract: PRASENT STATUS AND PRSPECT OF COPPER RADIOPHARMACEUTICALSChen Huawei;Li Hongfeng; Liu Boli(Chemistry Department Beijing Narmal University,100875)Abstract:In the past decade most of the efforts of copper radiopharmaceuticals research has been focused onbis (thisoemicartheonato) copper complexes for use in myocardial and brain imaging agents. In the present work, the analogs of bis(thiosemicarbazone) is studied in labeling antibodies and tumors. The retention mechanism of Cu-PTSM is investigated. Other kinds of ligands, BAT(N2S2) for example, canbe used to prepers neutral copper complexes in order to obtain brain radiopharmaceuticats in future.Keywords: copper radiopharmaceuticals. myocardial and brain imaging agent monoclonal antibody bis (thisosemicarbazonato) copper pharmaceutical retention mechanism