Abstract: QUALITY CONTROL IN PROCEING ~(153)Sm-EDTMPP REPARED WITH NATURAL ABUNDANCE SAMARIUM TARGETJin Xiaohai;Liu Yuemin; Du Jin; Wan Fan;Chen Deming; ai Hongsheng; Zhao Xiuyan(China Institute of Atomic Energy, Beijing 102413)Abstract:The HPLC analysis shows that Sm-EDTMP and 153Sm-EDTMP contain no organic impurity. Theradionuclide purity of 153Sm is about 99. 7%. Autoradiolysis will make no contribution when the solution of 153Sm-EDTMP is with a radioactive concentration of less than 1. 85 GBq/ml. For the short halflife of 153Sm, the column chromatographic method needs only 5-10 min for radiochemical purity analysis, while the paper chromatography needs 2-3 h. Animal tests show that there is no obvious difference between the biodistribution results in rats for the natural target prepared 153Sm-EDTMP and the enriched Sm2O3 prefered 153Sm-EDTMP.Keywords: natural abundance target 153Sm-EDTMP quality control