Abstract: PREPARATION OF 3-(2-PHENYL-2-CYCLOPENTYL-2-HYOROXYETOHXY)3-~3HQUINUCLIDINELi Deyou;Yan Junhua;Wu Liang;Chen Lanfu(Institute of Pharmacology and Toricology, Acodemy of Military Medical Seiences, Beijing 100850)Shen Decun(China Institute of Atomic Energy, Beijing 102413)Abstract:For preparation Of 3-(2-phenyl-2-cyclopentyl-2-hydroxyethoxy) 3-3H quinuclidine, firstly3-3Hquinuclidol is prepared by catalytic tritiation of quinuclidone with PtO2. Then from the reactionof 3-3Hquinuclidol and l-phenyl-1-Cyclopentyl-cyclo ethane, the target product can be obtained.The specific activity is 740 TBq/mol, and the radiochemical purity is over 95%.Keywords: tritium-labeled; 3-(2-Phenyl-2-cyclopentyl-2-hydroxyethoxy )3-~3Hquinuclidine3-~3Hquinuclidol