α1─MGRIA在肾脏疾病诊断中的应用

  • 摘要: 应用α1-MG放射免疫分析法(α1-MGRIA),对276例正常人(对照组)的血清和尿进行了检测。结果表明:血清正常值为54.22±22.02mg/l,尿正常值为5.57±2.63mg/l。同时对358例不同疾病患者也进行了检测,其中妊高症、肾功能不全、肾炎等疾病组尿α1-MG含量与对照组比较有显著性差异(P<0.001),为临床肾脏疾病诊断及肾功能检测提供了可靠、灵敏的指标。该法可在临床上推广应用。

     

    Abstract: THEAPPLICATIONOFα1┐MGRADIOIMMUNOASSAYINTHEDIAGNOSISOFKIDNEYDISEASESLiuGuifenWangJianchunZhangQingfengLiuShuyingHanWensheng(CangzhouCentralHospital,061001)LiZhihong(CangzhouHealthSchool,061001)ABSTRACTAnewmethodforthediagnosesofkidneydiseaseswithα1-microglobulin(α1-MG)ra-dioimmunoasayisdeveloped.276healthypersonsserumandurinearedeterminedbyα1-MGradioimmunoassay.Theresultshowsthattheserumnormalnumberis54.22±22.02mg/landtheurine5.57±2.63mg/l.Incontrast,thecounterpartsof358patientswithdif-ferentdiseasesarealsoexamined.Theresultshowsthatthereisaremarkablediferencebe-tweenurineα1-MGcontentofpatientssuferingfromsuchdiseasesasgestationhyperten-sion,renalinsuficiency,nephritisandthatofthehealthygroup(P<0.001).Themethodprovidesastable,sensitiveindexforthediagnosesofkidneydiseasesandtheexaminationofkidneyfunction.Itcanbewidelyusedintheclinicaldiagnosis.Keywordsα1-microglobulinradioimmunoassaykidneyfunctionkidneydiseases

     

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