血、尿α1─微球蛋白和尿白蛋白联合检测对肾功能的评价

  • 摘要: 血、尿α1-微球蛋白(α1-MG)及尿白蛋白(Alb)联合检测可作为肾功能损害早期诊断的灵敏指标。对221例各类肾脏疾病患者和57例正常人(对照组)的血和尿α1-MG、β2-微球蛋白(β2-MG)及尿Alb进行了放免检测。结果表明:患者血和尿α1-MG、β2-MG及尿Alb值均明显高于对照组(P<0.001和P<0.05)。患者阳性率:血和尿的α1-MG分别为82.4%和84.2%;血和尿的β2-MG分别为79.6%和73.3%;尿Alb为91.4%。显示了α1-MG、Alb阳性率高于β2-MG,故在各种肾病早期诊断和恢复期观察应首选α1-MG和Alb。

     

    Abstract: THECOMBINEDDETERMINATIONOFSERUMANDURINARYα1┐MGANDURINARYALBUMINFORTHECLINICALAPPRAISALOFKIDNEYFUNCTIONShengChunyongWangChunlan(CenterPeoplesHospitalofTengzhouCity,ShandongProvince,277500)MaYuantao(HospitalofZhaozhuangCity,ShandongProvince,277100)ABSTRACTThecombineddeterminationofserumandurinaryα1-MGandurinaryalbumin(Alb)canbeusedasthesensitiveindicesoftheearlydiagnosisofkidneyfunction.Theserumanduri-naryα1-MG,β2-MGandurinaryAlbvaluesfor221caseswithdiferentkidneydiseasesand57normalsubjectsaremeasuredbyradioimmunoassay.Theresultsshowthatthevaluesofserumandurinaryα1-MG,β2-MGandurinaryAlbofpatientsaresignificantlyhigherthanthatofhealthysubjects(P<0.001andP<0.05).Thepatientspositiveratesofserumandurinaryα1-MGis82.4%and84.2%respectively,serumandurinaryβ2-MGis79.6%and73.3%respectively,andurinaryAlbis91.4%.Itissuggestedthatthepositiveratesofserumandurinaryα1-MGandurinaryAlbishigherthanthatofserumandurinaryβ2-MG.Sothedeterminationofα1-MGandAlbshouldbeusedintheearlydiagnosisandrecoveryobservationofdiferentkidneydiseases.Keywordskidneydiseasesradioimmunoassayα1-microglobulinalbumin

     

/

返回文章
返回