糖皮质激素及其受体在肾病综合征中的意义

  • 摘要: 应用受体放射分析技术检测了34例肾病综合征(NS)患者及40例对照组的外周血淋巴细胞糖皮质激素受体(GCR)。结果显示:患者GCR水平与糖皮质激素(GC)的疗效密切相关,对GC治疗敏感者,其GCR水平高于对GC无反应者(P<0.01)及对照组(P<0.01)。同时检测了NS患者及对照组血浆促肾上腺皮质激素(ACTH)和皮质醇的含量,发现NS患者ACTH及皮质醇含量明显低于对照组(P<0.05),但与GC疗效未见明显相关性。

     

    Abstract: SIGNIFICANCEOFGLUCOCORTICOIDSANDTHEIRRECEPTORSINPATIENTSWITHNEPHROTICSYNDROMEYangLiusongLiDapeiLiuDeyiWangWeiyueWangHaodan(RadioisotopeLaboratoryofShangdongMedicalUniversity,Jinan250012)ABSTRACTTheglucocorticoidreceptor(GCR)in34patientswithnephroticsyndrome(NS)and40normalcontrolsisinvestigatedbyradioligandbindingasay.TheresultsshowthattheGCRlevelsofNSpatientsarecorrelatedwelwiththetreatmentresultsbyglucocorticoids(GC).ThesepatientswhoaresensitivetoGCtreatmenthavemuchhigherlevelsofGCRthanthosewhoarenotresponsivetoGCtreatment(P<0.01)andthenormalcontrols.TheplasmaACTHandcortisolinthesamesubjectsarealsomeasuredandtheresultsshowthatNSpa-tientshavemuchlowerlevelsofthesetwohormonesthanthenormalcontrols,butnosig-nificantcorrelationisnotedbetweenthelevelsandtheGCtreatmentefects.KeywordsglucocorticoidreceptorACTHcortisolnephroticsyndrome

     

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