Abstract:
SIGNIFICANCEOFGLUCOCORTICOIDSANDTHEIRRECEPTORSINPATIENTSWITHNEPHROTICSYNDROMEYangLiusongLiDapeiLiuDeyiWangWeiyueWangHaodan(RadioisotopeLaboratoryofShangdongMedicalUniversity,Jinan250012)ABSTRACTTheglucocorticoidreceptor(GCR)in34patientswithnephroticsyndrome(NS)and40normalcontrolsisinvestigatedbyradioligandbindingasay.TheresultsshowthattheGCRlevelsofNSpatientsarecorrelatedwelwiththetreatmentresultsbyglucocorticoids(GC).ThesepatientswhoaresensitivetoGCtreatmenthavemuchhigherlevelsofGCRthanthosewhoarenotresponsivetoGCtreatment(P<0.01)andthenormalcontrols.TheplasmaACTHandcortisolinthesamesubjectsarealsomeasuredandtheresultsshowthatNSpa-tientshavemuchlowerlevelsofthesetwohormonesthanthenormalcontrols,butnosig-nificantcorrelationisnotedbetweenthelevelsandtheGCtreatmentefects.KeywordsglucocorticoidreceptorACTHcortisolnephroticsyndrome