Abstract:
RIAOFPLATELETGMP┐140INPATIENTSWITHCORONARYHEARTDISEASEDuTongxinWangZizhengShiHongzhenLuXuelongLiuJiaqin(NanjingMedicalRadioimmunoasayCenter,210006)GongHeheZhangZhengyi(CardiacDepartment,NanjingHospitalNo.1,210006)ABSTRACTWithmonoclonalantibodySZ-51,theactivatedlevelsoftheplateletgranulemembraneprotein(GMP-140)of94caseswithcoronaryheartdisease(CHD)areassayedbyRIA.TheresultsshowthatthelevelsofGMP-140withCHDaremuchhigherthanthoseofthecon-trols(P<0.001),andthelevelsofGMP-140withAMI12hoursafterthetreatmentwithurokinaseforthrombolysisareconsiderablylowerthanthelevelsonehourbeforethetreat-ment.Therefore,theassayofGMP-140withCHDisofgreatclinicalsignificanceindiagnos-inganddiferentiatingCHD,especialy,inanalysingpathogeny,monitoringcurativeefectandpredictingprognosisforAMI.Keywordsplateletgranulemembranecoronaryheartdiseaseradioimmunoassay(RIA)