Abstract: THE DIAGNOSTIC VALUE OF SERUM AFP VARIANTS ON THE LIVER DISEASE PATIENTS Xiong Su Wu Wenfang Zhou Ning Bao Xiushen（Nuclear Medicine Department of the Central Hospitol in Jianghan Petroleum Administative Bureau， Hubei 433124）ABSTRACT 30 cases of primary liver cancer and 30 cases benign liver disorders are studied with radioim-munoassay AFP and pisum sativum agglutinin by affinity crossed immunoelectrophoresis autoradiography（PSA-CIEA）．The results show that differentiation of primary liver cancer frorn benign liv-er disorders seems to be difficult by determination of total amount of serum AFP. However, humanAFP can be separated into two variants PSA bound AFP and PSA unbound AFP with PSA-AFF-CIEA. The percentage of PSA bound AFP is significantly higher in the presence of primary liver can-cer（41．26％±19．47％）than in benign liver disorders（15．96％±12．09％，p＜0． 001）．The results possess higher clinical value to diagnose the positive lower level of primary liver cancer and benign liver disorders by using PSA-AFF-CIEA. Key words AFP variants PSA-AFF-CIEA