Abstract: THE SYNTHESIS IF 3-~(14)CINDIRUBIN Gu Meiying；Zhang Xiuwen；Tian Shuhao（Institute of Radiomedicine,Chinese Academy of Medical Sciences,Tianjin 300192）ABSTRACT 3-~(14)Cindirubin is synthesized in three steps from potassium ~(14)Ccyanide. First，Potassium~(14)Ccyanide reacts with N，N′-diphenyltbiourea to get N，N′-diphenyl~(14)Ccyanoamidine，Then.cyclizated in the presence of anhydrous aluminium chloride and hydrolizated with hydrochloric acid，amidine is leaded to3-~(14)Cisatin，Finally，3-~(14)Cisatin is condensed with excess potassium 3-indole-late to yield3-~(14)Cindirubin in 20． 34％overall radiochemical yield from K~(14)CN with a specific activi-ty of 2 GBq／mmol and a radiochemical purity of 99．9％（TLC）.Key words potassium~(14)Ccyanide3-~(14)Cindirubin synthesis