Abstract: SIGNIFICANCE OF SERUM AND URINEβ_2－MG ABNOKMALITY FOR DIABETESYu Fengling；Zhang Qiliang；Feng Zhixu；Hou Xiangzhen（Department of Nuclear Medicine of Weifang People Hospital,Shandong 261041）ABSTRACT Levels of serum and urineβ_2－MG are determined in 114 patients with diabetes．It is found thatlevels of serum and urineβ_2－MG in diabetes are significantly higher than that of normal contrasts（P＜0．01）．Levels of serum and urineβ_2－MG are increased with diabetes Drogress，especially urineβ_2－MG． There is no difference in levels of serum and urineβ_2－MG between noninsulin dependent diabetesmellitus（NIDDM）and insulin dependent diabetes mellitus（IDDM，P＞0．05）．Urineβ_2－MG levels ofdiabetes are relatively increased with the increase of serumβ_2－MG levels．Both are obviously positivecorrelation. While diabetes progressing，both are gradually increased．It can be shown that the longerdiabetes process，the more renal function was damaged．Therefore，determination ofβ_2－MG is very im－portant for early diagosing，preventing and treating diabetic nephropathy．Key words　diabetes serum and urineβ_2－MG　radioimmunoassay