可望用于肿瘤治疗的~(103,109)Pd胶体的制备及其生物性质评价

  • 摘要: 采用天然丰度钯粉(纯度≥99.95%)作靶料,经反应堆照射后,用HNO_3、HCl氧化生成放射性氯铂酸盐;在一定酸度的条件下,以抗坏血酸作还原剂,葡萄糖和明胶作保护剂,获得氧化态为零价的钯原子胶体(游离钯离子<0.5%)。经电子显微镜测得胶体的粒度范围为100—400nm。动物实验表明: ̄(103,109Pd胶体高度浓集于体腔的肿瘤部位,血清除快,关节显像清晰,给大鼠注入相当于人体用量100倍的 ̄(103,109)pd胶体,未观察到毒副作用。

     

    Abstract: THE PREPARATION AND BIOLOGICAL EvALUATION OF A POTENTIAL TUMOR THERAPEUTIC~(103),~(109)PdRADIOCOLLOIDLiu Zhonglin;Luo Shunzhong(southwest Institute of Nuclear Physics and chemistry,chengdu 610003)Dai Ting'en(General Hospital of kunming Military Region,650000)ABSTRACT The~(103),~(109)pd radiocolloid is obtained after treating irradiated metallic palladium powder in reactorwith nitric acid and hydrochloric acid in the presence of ascorbic acid(reducing agent)as well as glu-cose and gelatin(protectiue agent).The size of Pd radiocolloid particles is in the range of 1 5 0一400nm. Animal tests indicated that the~(103).~(109)pd colloid can be concentrated highly into the tumor of rab-bits. No toxic effect is observed when the~(103),~(109)pd radiocolloid is injected into a rat in a dose as muchas 1 00 times of that for a patient(1.
    2GBq/50 kg). Key words ~(103),~(109)pd radiocolloid tumor bio-evaluation

     

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