铼放射性药物的现状和展望

  • 摘要: 将铼放射性药物分为亲肿瘤药物、亲骨药物和胶体药物,近十几年来,发展迅速,其中亲肿瘤药物的研究最多,在药物化学、标记技巧及医疗应用等方面的研究比较充分;其次是亲骨药物,这类药物与恶性肿瘤有密切关系,它是各种软组织恶性肿瘤骨转移后的显像和止痛药物;铼的胶体药物应用尚不广泛。本文在评述了上述各类药物现状的基础上,试图进一步展望今后铼放射性药物的发展方向。

     

    Abstract: THE CURRENT STATE AND PROSPECT OF THE RHENIUM RADIOPHARMACEUTICALSLiu Guozhen;Liu Boli(Radio and Radiation Chemistry Divsion,Chemistry Department,Beijing Normal University 100875)ABSTRACT The rhenium radiopharmaceuticals have developed,rapidly within recent dozen-plus years.Theycan be classified as tumor-seeking.bone-seeking and colloid radiopharmaceuticals.Among them,thereare more research on tumor-seeking radiopharmaceuticals,and their mdical application.chemical theories,labelling techniques have been under comparatively thorough study.The rhenium bone-seckingradiopharmaceuticals come the second.they have also much to do with the cancer,with the ability ofpalliating the pain caused by bone cancer sites.With regard to the colloid radiopharmaceuticals their application is not widespread.On the basis of the current state of the radiopharmaceuticals,this review isatttempted to forecast the direction of the development of rhenium radiopharmaceuticals is the future.Key words rhenium radiopharmaceuticals tumor-seeking radiopharmaceuticals bone-seekingradiopharmaceuticals colloid radiopharmaceuticals.

     

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