乳过氧化物酶法制备~(125)Ⅰ标记膀胱癌(L_4B_4)单克隆抗体技术

PREPARATION OF ~(125)I-LABELED MONOCLONAL ANTIBODY OF BLADDER NEOPLASM USING LACTOPEROXIDASE

摘要: 采用乳过氧化物酶(LPO)放射性碘化标记技术,制备了~(125)I标记的膀胱癌单克隆抗体(L_(4)B_(4)),用于荷(L_(4)B_(4))瘤的裸鼠放射性示踪实验,~(125)I-L_(4)B_(4)浓集在肿瘤部位.

Abstract: 125I-labled monoclonal antibody of bladder neoplasm (125I-L4B4) is prepared using lactoperoxi-dase. The in-vivo radioactive distribution of 126I-L4B4 in bare mice shows that 125I-L4B4 concentrates in the tumour.