Abstract: CHANGES OF BLOOD INSULIN AND C-PEPTIDE CONCENTRATIONS IN PATIENTS WITH HYPERTHYROIDISM BEFORE AND AFTER TREATMENTYang Zongyu；Gou Shuqin；Lu Yaping Zhang；Yanqiu（Department of Nuclear Medicine,People＇s Hospilal,Beijing Medical University,100044）AESTRACT Release curves of blood insulin and C-peptide stimulated by bread test are analysed before and aftertreatment for the hyperthyroidism in 32 cases. It is found that stimulated blood glucose level of the pa-tients is significantly higher than that of normal controls at 30 and 60 minutes.The blood insulin and C-peptide levels are also abnormally higher though not statistically significant.After effective treatment for the hyperthyroidism，the postprandial release curves of blood glucose,insulin and C-peptide return backto normal．The results show that hyperthyroxinemia in such circumstances has not irreversible effects onthe function of pancreatic βcells. Key words hyperthyroidism glucose insulin C-peptide