~(90)Y标记单克隆抗体用于放免治疗的研究Ⅰ.四种~(90)Y标记物的24小时生物分布的比较

摘要: 研究了（９０）￣ＹＣｌ＿３，（９０）￣Ｙ－ＤＴＰＡ，（９０）￣Ｙ－ＤＯＴＡ和（９０）￣Ｙ－ＤＴＰＡ－ＩｇＧ的制备方法及其在小鼠体内的生物分布。（９０）￣ＹＣｌ＿３的主要积聚器官是骨，在其它组织代谢较快。（９０）￣Ｙ－ＤＴＰＡ和（９０）￣Ｙ－ＤＴＰＡ－ＩｇＧ在体内有较严重的（９０）￣Ｙ脱落；（９０）￣Ｙ－ＤＯＴＡ有效地改善了（９０）￣Ｙ在骨中的积聚，表明大环ＤＯＴＡ类衍生物是（９０）￣Ｙ标记单克隆抗体良好的配体。

Abstract: LABELING MoAb WITH ~(90)Y EOR RADIOIMMUNOTHERAPY Ⅰ．BIODISTRIBUTIONS FOR FOUR ~(90)Y-LABELED COMPOUNDS AT 24 HOURS AFTER ADMINISTRATION Wu Yonghui; Liu Bin; Zuo Yuhong; Liu Qimin（Department of Technical Physics, Peking University, Beijing 100871）ABSTRACT ~(90)YCl_3，~(90)Y-DTPA ~(90)Y-DOTA and ~(90)Y-DTPA-IgG were prepared and their biodistributions are in-vestigated． Unchelated ~(90)Yachieves a high uptake in bone and has a rapid clearance in other tissues；There is a serious loss of ~(90)Y in vivo from ~(90)Y-DTPA and ~(90)Y-DTPA- IgG；~(90)Y-DOTA obviously re-duces the accumulation of~(90)Yin bone. The result shows that DOTA is a prospective bifunctional chelat-ing agent for labeling MoAb with~(90)Y. Key words radioimmunotherapy labeling monoclonal antibody biodistribution