血、尿THP放射免疫分析的医学诊断

  • 摘要: 用THPRIA药盒,对101名正常人的血、尿THP进行检测:血THP为159.89±5l.57ng/ml,尿THP为28.84±14.99mg/24h,与国内外学者报道相近。对298例8种肾脏病患者血、尿THP值进行了检测,尿THP值均比正常人有明显下降。经统计学处理,慢性肾衰、间质性肾炎、慢性肾炎、狼疮性肾炎、糖尿病性肾病、尿路感染等7种疾患均有非常显著差异;而血中THP值只有前4种有非常显著差异,其余无差异,提示尿样检测优于血样检测。在对279例肾病患者检测血、尿THP值的同时,还检测了血、尿β_2-MG、尿Alb、血液尿素氮(BUN)和血Cr。血、尿THP值对各种肾病的总异常率低于尿Alb和β_2-MG,但高于BUN和血Cr。

     

    Abstract: MEDICAL DIAGNOSIS OF RADIOIMMUNOASSAY FOR THE THP IN BLOOD AND UNINE zhu Guila Xu Sumei Chen Linna(Department of Nuclear Medicine,The Affiliated Hospital of Zhen jiang Medical Couege,212001)ABSTRACT The Tamm-Horsfall protein(THP)in bloob and urine of 10 1 healthy subjects and29 8 cases ofpatients with 8 different kinds of diseases are de tected by RIA kit.The average values of THP inheaIthy subjets' bIood and urine are l 59.89±51.57 ng/ml and 28.84±14.99 mg/24 h respective-ly,It is the same as detected by other authors. The resuIts show that the level of urine THP of Pa-tients ,including chronic renal failure,interstitiaI nephritis,chronic nephritis,lupus nephritis,diabet-ic nephritis and urinary infections,are much lower than that of heaIthy subjects(P<0.001),but thelevel of blood THP,are only lower in 4 kinds diseases,e.g.chronic renal failure,interstitial nephri-tis,chronic nephritis and lupus nephritls.In addition,theβ_2-MG in blood and urine,albumin in urineand BUN,Cr in blood in 27 8 cases are detected.It is found that the total abnormal rate of the bloodand urine THP is quite lower than that of urine albumin and β_2-MG,but higher than blood BUN andCr.Key words kidney disease radioimmunoassay tamm-horsfall protein

     

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