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新的心血池显像剂~(99)Tc~m-DTPA-HSA的实验研究

    摘要
  • 摘要: ￣（９９）Ｔｃ￣ｍ－ＤＴＰＡ－ＨＳＡ心血池显像剂于２０只家兔进行实验研究，并与￣（９９）Ｔｃ￣ｍ－ＲＢＣ（体内法）及￣（９９）Ｔｃ￣ｍ－ＨＳＡ进行比较。由￣（９９）Ｔｃ￣ｍ－ＤＴＰＡ－ＨｓＡ所得心血地显像的图像清晰。生物学分布研究表明，￣（９９）Ｔｃ￣ｍ－ＤＴＰＡ－ＨＳＡ在肝和肺的地聚较￣（９９）Ｔｃ￣ｍ－ＲＢＣ及￣（９９）Ｔｃ￣ｍ－ＨＳＡ略低。心／肝放射性比值，￣（９９）Ｔｃ￣ｍ－ＤＴＰＡ－ＨＳＡ为０．８５，￣（９９）Ｔｃ￣ｍ－ＲＢＣ为０．９５，￣（９９）Ｔｃ￣ｍ－ＨＳＡ为０．６２。动物研究结果证明，ＤＴＰＡ与ＨＳＡ螯合后制成的心血池显像剂稳定性好，所得心血池显像清晰，且仅一次注射，值得进一步研究。

     

    Abstract: STUDY ON ~(99)Tc~m-DTPA-HSA AS A NEW BLOOD POOL SCANNING AGENT Liu Yunzhong Zhang Zheng Wu Qingwen Guo Feng Liu Huaping Zhang Weihe Zhou Baogui Liu Xiujie（Fuwai Hospital,CAMS,Beijing 100037）Tang Hong Lin Qiongfang（China Institute of Atomic Energy, Bei jing，102413）ABSTRACT The biological behavior of~(99)Tc~m-DTPA-HSA，~(99)Tc~m－RBC（in vivo）and ~(99)Tc~m-HSA are studied inrabbits，Excellent cardiac blood-pOOl images are obtained by~(99)Tc~m-TPA-HSA and~(99)Tc~m-RBC.Biodis-tribution studies show that~(99) Tc~m-DTPA- HSA has less accumulation than~(99) Tc~m-RBC in lungs and liV-er，they have similar count ratio of the cardiac blood pool to whole body，ratio of heart/liver is 0.85for ~(99)Tc~m－DTPA-HSA，0.9 5 for~(99)Tc~m-RBC and 0.6 2 fOr~(99)Tc~m-HSA.~(99)Tc~m-DTPA-HSA is a promis-ing agent．It is readily performed only by single in vivo injection.Key words cardiac blood pool scintigraphy ~(99)Tc~m-DTPA－HSA

     

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