Abstract: THE DISTRIBUTION OF ~(3)H-D-HAMS IN RAT LIVER Zhogn Weiqiang Guan Shouren Wang Renzhi（Institute,of Radiatiiion,Beijing 100850）ABSTRACT By means of autoradiographic and radioactivity counting metheds，it is shown that~(3)H-Dau re-tained in rat liver is significantly higher（tens to hundreds times）and longer by route of intraportal in-jection of ~(3)H- Dau-HAMS than by intraporitoneal injection of ~(3)H- Dau，and there are morphologicalchanges of nectosis induced by microsphere embolization and sutbsequent regeneration. The resuIts indi-cate that chemotherapeutic microspheres might play a dual role of embolization and therapeutic enhance-ment effects. Key words drug mictosphere radioautography ~(3)H-daunomycin