Abstract: The combined determination of β_2-M, THP, Alb, IgG may be used as the sensitive indication of the early degeneration of kidney function. The paper observed 107 cases, and found that the anomalous examine-out ratios of haemorrhage β_2-M and UTHP are 50.75% and 65.67% respectively, 1.5—2.3 times higher than the C_(cr) anomals examine-out ratio. The radio-immunoassay of β_2-M and THP is a better measure for discovering light kidney function injury in early period than C_(cr) method. The clinical value of the radio-immunoassay of β_2-M, THP is obviously better than the traditional and classical method. The diseases of anybody system may influence the kidney function through various mechanisms. The retrogression of kidney tissue of the patients in old-and mid-age leads to decrease of kidney function. The combination of β_2-M and THP has the highest anomalous examine-out ratios of kidney function; the next is urine Alb.