Abstract: The report describes the results of laboratory observations of liver and kidney in mice body by the following methods: (1) scintillation measurement for liver and kidney samples of mice, which feed on yolk of eggs labelled with ~(65)Zn, (2) light microscopic-autoradiograph (ARG) observation of liver and kidney samples labelled with ~(65)Zn and (3) immuno-histochemistry staining analysis by calcium-cobalt method for AKP enzymes of liver and kidney samples. Results indicated that ~(65)Zn have been integrated with yolk of egg in the course of biological-conversion, making up a metal protein (metallothioneine) and offering advantageous conditions for absorption utilization of zinc in the body. The study provides theoretical basis for clinical applications of high-zinc eggs.