~(99m)Tc-血池显像剂及临床初步应用

THE PREPARATION OF ~(99m)Tc-BLOOD POOL IMAGING AGENT AND CLINICAL PRELIMINARY APPLICATION

摘要: 本文报道了用亚锡-焦磷酸盐在体内标记~(99m)Tc-红细胞作为血池显像剂;探索了影响体内~(99m)Tc-红细胞标记率的因素:用药量、药物pH值和~(99m)Tc的放射性浓度;制成了供临床使用的药盒。使用该药,只要用药量在(0.1—0.2)mg/kg体重时,就能在体内得到标记率大于96.0％的~(99m)Tc-红细胞。临床上30个病例证明了该药盒能得到清晰的心血池和肝血池显像。

Abstract: This paper describes the way of in vivo labelling of the blood pool imaging agent ~(99m)Tc-RBC by stannous-pyrophosphate method. The radioactivity concentration of ~(99m)Tc-pertechnetate, the dose and the Hp of the pharmaceuticals, factors which effect the efficiency of the labelling were studied. The kit has been made for clinical use. The labelling efficiency of more than 96.0％ can be obtained as long as the dose of 0.1—0.2mg/kg body weight is used. It was proved by clinical uses to 30 patients that this kit could show the images of blood pools of heart and liver clearly.