新的脑显像剂~(99m)Tc-ECD的研制——Ⅰ.合成与标记条件

DEVELOPMENT OF ~(99m)Tc-ECD AS A NEW BRAIN IMAGING AGENT Ⅰ.SYNTHESIS AND LABELLING

摘要: 通过二步反应合成了ECD(Ethyl Cystenate Dimer)。利用~(99m)Tc-GH与ECD之间的配体交换反应,制得~(99m)Tc-ECD。研究了温度,pH值,Ca-GH的浓度,SnCl_2的浓度等对标记百分率的影响。结果表明,pH值的影响是非学重要的。

Abstract: ECD (Ethyl Cysteinate Dimer) was synthesized by two-step reactions. ECD was labeled with ligand exchange reaction between ~(99m)TcGH and ECD. The effect of temperature, PH Value, various quantities of Ca-GH, Sncl_2 on labelling percentage was studied. The effect of pH value is very important.