鲎试验检查放射性药品细菌内毒素(热原)的实验研究

A STUDY ON BACTERIAL ENDOTOXINS TEST OF RADIOPHARMACEUTICALS WITH LIMULUS AGENT

摘要: <正> 一、引言鲎试验是利用一种栖生于海洋中的节肢动物“鲎”的血细胞溶解物(鲎试剂TAL)与微量细菌内毒素发生凝胶反应的一种实验。这是一种体外的生化测定方法,反应速度和凝胶的牢固度与内毒素的浓度相关。目前,许多国家已将鲎试验法用于药品热原和临床快速检验。1980年美国首先将鲎试验以“细菌内毒素试验”条目收载于美国药典(第20版),

Abstract: The feasibility of endotoxins test of radiopharmaceuticais with limulus agent and the approach to take off the inhibition/enhancement effect of radiopharmaceuticals on limulus agent have been studied. Results of the test for 8 radiopharmaceutieals have also been given.