Abstract: This article describes a double-function conjugation method of~(99)Tc-labelled ranitidine, First of group (NO_2) of ranitidine was reduced with SnCl_2 under the special conditions, and then DTPA anhydride was conjugated with it. The reaction mixture must be purified to separate free DTPA from R-CDTPA by dialysis method. RCDTPA Was labelled with ~(99m)TC. The labelling yield Was determined by paper chromatography, radiochemical purity of ~(99m)Tc-R-CCTPA is more than 99%. The initial results of clinical experiments have shown that the dynamic studies of ranitidine drug in vivo are very satisfied.