~(67)Ga,~(113m)In,~(201)TI标记BAT类螯合物的研究——Ⅱ.BAT螯合物净电荷及稳定常数测定

STUDIES ON DERIVATIVES OF BAT CHELATES LABELLED WITH ~(67)Ga, ~(113m)In AND ~(201)TI——Ⅱ. DETERMINATION OF NET CHARGES AND STABILITY CONSTANTS OF BAT CHELATES

  • 摘要: <正> 一、引言 文献1报道用~(67)Ga,~(113m)In,~(201)T1标记BAT类(1,2-二巯基-5,8-二杂氮环癸烷)螯合物能在小鼠体内心肌浓集,它是一类值得研究的新的心肌显像剂。本文进一步研究了这类螯合物的净电荷和络合稳定常数,用来解释这类放射性药物在动物体内分布所得到的满意结果。

     

    Abstract: The net charges of the new potential myocardial imaging chelates M-BAT-TE and M-BAT-HM (M=Ga~(3+), In~(3+), Tl~(3+)) were determined by means of the ion exchange resin method.The net charges of these six chelates were all identified as + 1. In determining stability constants the pH eiectric potential method was used. The experimental results show that the magnitudes of the stability constants are in such an order: Tl-HM>In-HM>Ga-HM; TL-TE>In-TE>Ga-TE. This order is identical to the order of the heart uptake in mice of these chelates.

     

/

返回文章
返回