G-~3H18甲-三烯炔诺酮的制备

PREPARATION OF TRITIAIED 18-METHYLNORGESTRIENON

摘要: <正> 一、前言 18甲-三烯炔诺酮是一种抗着床用的新型口服避孕药。为研究它的药代动力学参数,即药物在体内的吸收、分布、排泄等代谢过程及其规律性,为临床合理用药提供安全、有效的数据,所有这些实验都需要它的氚标记物作为示踪剂。为此我们采用氚水交换法直接进行标记,用薄层色层法分离纯化产品,最终产品的比活度为59.2TBq/mol,放化纯度>98％,完全满足实验的要求。

Abstract: Tritiated 18-methyl-norgestrienon was prepared by catalytic exchange with tritiated water in the presence of 10％ Pd/C. The final product was separated and purified by thin layer chromatography. Its specific radioactivity and radiochmical purity were 59.2 TBq/moL and 98％ respectively.